How Dupilumab Can Help with Long Term Eczema Management

Dr Sue-Ann Ho Ju Ee, Medical & Surgical Dermatology Clinic, Novena Medical Centre, Singapore

Eczema That Just Won’t Go Away

If you're frequently battling itchy, red, inflamed skin that disrupts your comfort and sleep, you may be dealing with atopic dermatitis, the most prevalent form of eczema. In Singapore, this condition affects approximately 10–11% of adults. While moisturisers and medicated creams can be helpful for some, others may require more advanced therapies to manage persistent symptoms. One such option is Dupilumab, a newer form of treatment gaining attention in dermatology.

Why Some Eczema Needs More Than Creams

Atopic dermatitis is not simply dry skin. It’s a chronic inflammatory condition linked to immune system activity. Common triggers include heat, perspiration, allergens, and stress. Over time, the condition can impair the skin’s barrier.

Standard treatments such as emollients, topical corticosteroids, and antihistamines may offer relief. However, if flare-ups are frequent or cover large areas despite these measures, your dermatologist might suggest a more targeted approach.

What Is Dupilumab and How Does It Work?

Dupilumab, also marketed as Dupixent, is a biologic therapy. It is designed to modulate specific immune responses that drive eczema symptoms. By blocking interleukin-4 and interleukin-13, two key signals in eczema-related inflammation, Dupilumab reduces itching and skin lesions.

Unlike systemic steroids, Dupilumab does not suppress the entire immune system. It is typically prescribed for adults with moderate-to-severe eczema that has not responded well to other therapies. The medication is administered via subcutaneous injection every two weeks and can be combined with topical skincare regimens.

Is Dupilumab Safe?

Most patients tolerate Dupilumab well. The most commonly reported side effect are injection site reactions, eye irritation, including dryness or redness, which is generally mild and manageable. As Dupilumab targets specific immune pathways, it is considered safer for long-term use compared to general immunosuppressants.

Dupilumab is currently indicated for adult and pediatric patients 6 months and above. Initial injections are usually administered in a clinical setting. If assessed to be appropriate, patients may be taught to continue injections at home.

Who Might Consider Dupilumab?

You may be a candidate for Dupilumab if you:

• Have been diagnosed with moderate-to-severe eczema

• Experience frequent flare-ups despite using topical treatments

• Suffer from itch-related sleep disturbances

• Are seeking a non-steroid-based long-term treatment option

  
  

A comprehensive medical assessment is essential before starting this therapy. Not every patient is suitable, and individualised consultation with a qualified dermatologist is necessary.

What Happens After Starting Treatment?

Patients typically receive their first injection in the clinic, followed by education on self-administration if needed. Follow-up appointments will be scheduled to monitor your progress, manage side effects, and adjust your care plan accordingly.

Improvements may take time, it may take a few months for clinically meaningful changes. Adherence to the treatment plan and regular follow-up are crucial for achieving optimal results.

Where to Seek Help in Singapore

The Medical & Surgical Dermatology Clinic at Novena Medical Centre provides dedicated care in managing complex skin conditions, including eczema. Dr Sue Ann Ho Ju Ee offers evidence-based treatment planning and support tailored to individual skin needs.

Living with eczema can be challenging,

but effective long-term options like Dupilumab are now available. It may not be suitable for everyone, but for those struggling with persistent symptoms, it presents a promising alternative to conventional therapies.